Cyrus was an ever-hungry young vampire who had the misfortune to become one of Harmony's short-lived gang. He and his fellow minions traipsed around after Harmony, carrying out her doomed plans, one of which included trashing the Magic Box and killing it's owner. But Harmony just pushed too far when she decided to try and kill the Slayer, when her first attempt doesn't work (not helped by the fact that Buffy isn't home) she kidnaps Dawn and lures the slayer to her, who of course, kills all her minions, including poor Cyrus.
Andrew Wells was doomed from birth to live in someone else's shadow. First it was his brother Tucker, who famously, tried to disrupt Prom night by unleashing Hellhounds trained to kill people in formal wear. Of course, everybody remember this and forgot about Andrew spectacular flying monkeys gag.
But school was soon over and Andrew found himself meeting up with fellow nerds, Jonathan and Warren, together, they decided to take over Sunnydale. Now Andrew could live in the shadow of someone he really admired, Warren. Together the three of them hit Sunnydale with prank after prank, serving only to get on the Slayer's nerves, Andrew doing anything he can to suck up to Warren and leave Jonathan out in the cold. And of course much bickering. When the trio's latest plan becomes there last, Andrew and Jonathan find themselves both deserted by Warren and in prison. To make matters worse, Warren has to go and accidentally kill Tara, making her girlfriend Willow all mad and out on the rampage. After taking her revenge on Warren she comes looking for Andrew and Jonathan.
Fortunately Anya comes to the rescue and the pair head off to Mexico to hide from Willow and the law. Here they live in fear, having scary dreams and what's more The First Evil appears to Andrew in the form of the dead Warren and persuades him to return to Sunnydale and kill Jonathan, which he does.
But Sunnydale is not a lucky place for Andrew and he is soon discovered by Willow who drags him back to the Summers' house where he becomes the most willing hostage ever. Still desperately trying to fit in, Andrew does his best to help the scoobies and soon achieves some kind of redemption when his tears close the seal that he tried to open with Jonathan's blood. and double crossing. As the final battle approaches Andrew remains with the scoobies, and becomes useful in his own way, even managing to double cross The First when it tries to persuade him to more killing, and taking a field trio with Spike.
Andrew is there right to the end, fighting his corner alongside Anya, against the First and it's Bringers and Ubervamps, he even manages to survive the fight.
With the Hellmouth finally closed, Andrew starts training to become a watcher with Giles and discovers a liking for tweed. When Angel contacts Giles about a deranged Slayer who has escaped from a mental institution, Giles sends Andrew to investigate and, getting one over on Angel, Andrew leaves with the Slayer. The last we heard of Andrew he was in Italy with Buffy and Dawn, finally becoming noticed and getting some girls.