Ariel: - Ariel is a core planet with some brilliant medical facilities. Whilst Inara had a medical on the core planet Simon offered the crew a job. Mal and Zoë stole some drugs and medical supplies from St. Lucy's, the hospital, and sold them off.

Bellerophon: - A rich person's paradise. Each fairly well off person has their own estate, which is a floating island of their own above the planet's oceans. The floating islands have their own gardens, houses, everything a person could want. However the planet isn't completely water covered, there are areas of arid desert.

Eavesdown Docks: - A docking port on the planet of Persephone. Seen as a lower class slum area, a lot more less well to do ships land and dock here. This dock has been used on a few occasions by Serenity and was the place where Simon, River & Book first came aboard.

Higgins Moon: - The moon on which Canton is located, Higgins Moon's main export is mud and other such ceramic building supplies. The magistrate appears to be among the richest of the population, the rest of the population are workers, known as mudders, working in the mud fields. 

Kowlan Federal Base: -

Kowlan Federal Base is a large Alliance space station. Located close to the border of Jiangyin, these kinds of space stations make sure the skies are clear of illegal salvage operations, and other illegal activity. Serenity and her crew have to operate under the radar of such space stations.

Paradiso:  Mining city in the Georgia System. It has a problem with Bowdens Malady, an illness of some kind. Zoë and Mal were heading on a train to Paradiso, except they had to steal some cargo from the train, not knowing what it was. When they get to Paradiso and find out that the cargo was medical supplies, for a town which need them sorely, Mal & Zoë return the supplies to the sheriff.

Persephone: - A large populated planet. It has the typical high rise building area where all of the richer people live, but also the slum like areas of Eavesdown docks. Persephone's been visited a few times. 

Saint Albans: - Home planet of an old war buddy of Mal and Zoë's, Tracey. It's pretty much an ice world, where the temperature rarely goes above zero, snow is seen for much of the year. Wash has to maneuver Serenity above the planet, while being chased by the feds, in order to get Tracey home.

Santo: - Mal, Jayne & Inara went to a bar on the planet Santo and started a bar fight there too. They were there to get a job for themselves, which they did. Santo's said to be a less sophisticated planet, not far from Persephone.

Serenity Valley: - Serenity Valley was the site on which the most devastating battle of the battle of Unification took place. Located on Hera, this valley was a pivotal point, with high positioning points on both sides, and was fought over by the Alliance forces and the Independents for almost two months. There is where Mal and Zoë against Unification, on the side of the Independents.

St. Lucy's: - St. Lucy's is the hospital on the planet Ariel. In this hospital was a special scanning machine which allowed Simon to see River's brain and see what had been done to it. A typically large central planet hospital, with heavy security.

Tam Estate: - Simon and River Tam were brought up on this opulent looking estate on a planet called Osiris. Osiris is a very wealthy core planet and is where Simon studied and practice medicine for a very long time. Simon left Osiris and his wealthy life style in order to find and save River from the boarding school she had been sent to.

The Skyplex: - A Skyplex is a large space station with areas where people can live, entertainment areas and so on. Adelei Niska has his own Skyplex orbiting the planet Ezra, in the Georgia System. The crew visit another Skyplex during the episode The Message. Also a place where mail is collected and mail to.

Whitefall: - The fourth Athenian moon, a somewhat civilised planet. Most of which is run by Patience, who become mayor of one town there. The crew of Serenity go to Whitefall to make a deal with Patience.